<\/p>\n
The company found that, over time, the drugs cause a wide slowdown in aging clocks\u2014as much as 4 years in the case of a clock that looks at heart proteins. \u201cI think it\u2019s pretty clear that the organ age is shifting,\u201d said Aguayo-Orozco.<\/p>\n
The studies are also a huge boost for the science of aging clocks. Although these measures reflect a person\u2019s age, it\u2019s been uncertain if they are useful as true biomarkers. Now clock makers have evidence\u00a0 that their readouts show a drop in age when people take drugs with broad, well-demonstrated benefits.\u00a0\u00a0<\/p>\n
\u201cThe clock people have been pushing for a decade to get this kind of study done,\u201d says Yuge Ji, a biologist who previously worked in the field and now runs a startup, Reflector Bio. \u201cIt\u2019s huge for them.\u201d<\/p>\n
As part of its study, Novo took blood draws from 10,052 people, half on the drug and half on a placebo. Their blood, collected at the start of the study as well as months later, was then measured with \u201cproteomic clocks,\u201d which use levels of key proteins to predict a person\u2019s age and risk of dying.\u00a0<\/p>\n
Scientists at Eli Lilly performed similar research on their GLP-1 drug, tirzepatide, using so-called \u201cepigenetic\u201d clocks that assess age by counting accumulated changes to DNA. Lilly\u2019s study was smaller, but also found that for the most part, molecular time moved more slowly for people on the drug.\u00a0\u00a0<\/p>\n
\u201cAll the clocks are telling a consistent story that we\u2019re seeing a reduction in age,\u201d Kevin Duffin, vice president for aging research at Lilly, said during the conference. \u201cIt\u2019s not like we\u2019re going to reverse age by 30 years or something, but it\u2019s a significant reduction.\u201d<\/p>\n<\/p><\/div>\n
#Weightloss #drugs #show #signs #slowing #biological #aging #drugmakers<\/p>\n","protected":false},"excerpt":{"rendered":"
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