Supercooled kidneys<\/h3>\n
To test their device, Powell Palm and his colleagues first removed single kidneys from pigs. The organs were flushed with the same commonly used solution to remove the blood, just as transplant organs are. The team then kept some kidneys on ice for either two hours or 24 hours, to mimic standard conditions used in human transplantation. They also put some of the removed kidneys in their device for 24, 48, or 72 hours.<\/p>\n
The stored kidneys were then each transplanted back into the original donor pigs. Each pig\u2019s second kidney was removed in the same procedure, leaving each animal with only the kidney that had been stored, and reimplanted.<\/p>\n
Once the 24-hour supercooled kidneys were transplanted, they immediately began producing urine\u2014a key indication that they were working. The team members also measured other markers of kidney function and found that the organs appeared to be working normally within about 10 days of being transplanted.<\/p>\n
![\"Kidney](\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/07\/260722_livercooling_embed1.png?w=840\")
COURTESY RONALD SELLERS, POWELL-PALM LAB, TEXAS A&M UNIVERSITY<\/p>\n<\/figure><\/div>\n
That\u2019s slower than kidneys stored on ice for two hours but much quicker than kidneys kept on ice for 24 hours, says Powell Palm.<\/p>\n
The organs that were kept supercooled for 48 and 72 hours performed similarly, he says. \u201cEven at three days\u2014triple the clinical standard\u2014we\u2019re getting recovery that is faster than \u2026 [what has been] the gold standard for the last three decades,\u201d he says. \u201cSo we\u2019re really, really pumped about this.\u201d<\/p>\n
\u201cIt is impressive,\u201d says Heidi Yeh, a transplant surgeon at Mass General Brigham for Children, who also researches organ preservation technologies. \u201cOften kidneys that have been stored for 48 hours [in other studies] take a week or two before they start working again.\u201d<\/p>\n
Organs that grow<\/h3>\n
The supercooled organs seem to work well in the long term, too. Over a 30-day period, the pigs grew by around 30%\u2014and the kidneys grew with them, almost doubling in size to compensate for both the pigs\u2019 growth and the lack of a second kidney. The team monitored one of the pigs for 200 days before removing and analyzing its kidney. Even at that point the organ looked healthy, says Powell Palm. He and his colleagues presented the findings at the American Transplant Congress in Boston last month.<\/p>\n
Earlier this year, researchers in Canada showed they could also cool pig kidneys to below-zero temperatures and transplant them into pigs. The team\u2019s protocol included the use of a cryoprotectant, and organs were stored for up to 48 hours before being transplanted into pigs. Those organs survived for a week.<\/p>\n<\/p><\/div>\n
#Supercooled #kidneys #transplanted #pigs #landmark #achievement<\/p>\n","protected":false},"excerpt":{"rendered":"
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