<\/p>\n
Justice says a judging panel is now in the process of picking 10 finalists from 65 teams that have been exploring health foods, lifestyle interventions, digital trackers, and drug compounds.\u00a0<\/p>\n
Sinclair\u2019s team, Justice says, was a late entrant to the contest, but like all teams, it would be required to move into wider human tests starting this year. \u201cYou have to be ready and in trials,\u201d she says.<\/p>\n
The race to harness the reprogramming phenomenon and apply it to living people is heating up, even outside the XPrize competition. On June 2, a startup called NewLimit, founded by the crypto billionaire Brian Armstrong, said it had raised a further $435 million, from investors including Peter Thiel\u2019s Founders Fund, to support what it calls \u201cage reprogramming.\u201d\u00a0<\/p>\n
The company says it is working toward delivering genetic reprogramming instructions to the liver, to treat diseases of that organ.<\/p>\n
But Sinclair has been saying that whole-body rejuvenation is a possibility too. And for that, chemicals, rather than gene therapy, could be the most practical strategy.\u00a0<\/p>\n
Sinclair says his lab has been searching for such compounds and is starting to use AI \u201cto improve the oral agents that we\u2019re testing.\u201d<\/p>\n
Chemical reprogramming cocktails, as used in labs, typically involve a mix of vitamins, approved drugs, and experimental molecules. For instance, one recipe Sinclair filed a patent on includes the supplement forskolin,\u00a0 the antidepressant tranylcypromine, and an experimental chemical, laduviglusib, which has been tested against Alzheimer\u2019s, among other ingredients.<\/p>\n
\u201cIn those days it was a six-factor cocktail,\u201d Sinclair says of his earlier research. \u201cBut we\u2019ve come a long way. I can\u2019t disclose what’s in it, but it\u2019s an improvement and an advance on that, and we\u2019ve done a number of animal studies. They are not published, but we\u2019ve been doing them for a long time, and we want to make sure that we\u2019ve done a full investigation of safety and efficacy before we release any of the data.\u201d<\/p>\n<\/p><\/div>\n
#David #Sinclair #plans #test #wholebody #rejuvenation #drugs #XPrize #competition<\/p>\n","protected":false},"excerpt":{"rendered":"
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